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  • Title: New aminocyclitols as modulators of glucosylceramide metabolism.
    Author: Egido-Gabás M, Serrano P, Casas J, Llebaria A, Delgado A.
    Journal: Org Biomol Chem; 2005 Apr 07; 3(7):1195-201. PubMed ID: 15785807.
    Abstract:
    A series of 13 aminocyclitol derivatives belonging to two different families is described. Their configuration is governed by the regio- and stereocontrolled epoxide opening of a suitably protected conduritol-B epoxide. Studies on several glycosyl processing enzymes indicate that some of them are good inhibitors of glucosylceramide hydrolase. A rationale to account for preliminary structure-activity relationships is provided.
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