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  • Title: Synthesis and biological activity of some new flavone derivatives.
    Author: Bozdag-Dündar O, Ceylan-Unlüsoy M, Altanlar N, Ertan R.
    Journal: Arzneimittelforschung; 2005; 55(2):102-6. PubMed ID: 15787277.
    Abstract:
    In this study, a new series of 2-(4-[substituted benzylamino-methyl)-phenyl]-4H-benzopyrane-4-one (IVa-e) and N-substituted benzyl-N-[4-(4-oxo-4H-benzopyrane-2-yl)benzyl]-3-phenyl-acrylamide (Va-e) derivatives was synthesized and the results of their biological activity are reported. The synthesized compounds were tested for their in vitro antifungal and antibacterial activities. Compound IVa showed the best antifungal activity compared with miconazole (CAS 22916-47-8). Compound IVe indicated the same antibacterial activity compared with the control drug ampicillin (CAS 69-53-4).
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