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  • Title: A cytotoxic carotenoid from the marine sponge Prianos osiros.
    Author: Rogers EW, Molinski TF.
    Journal: J Nat Prod; 2005 Mar; 68(3):450-2. PubMed ID: 15787458.
    Abstract:
    Investigations of the marine sponge Prianos osiros, collected in Pohnpei, gave a new cytotoxic acetylenic carotenoid, (3R,3'R,5S)-3,3',5,19'-tetrahydroxy-7',8'-didehydro-gamma,epsilon-carotene-8-one. The absolute configuration of this carotenoid was solved by interpretation of IR, MS, and 2D NMR spectra and application of the modified Mosher's method. Compound 1 is cytotoxic toward cultured human colon tumor cells, HCT 116 (IC(50) 4.38 microg/mL).
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