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  • Title: Total synthesis of (+)-trans-195A.
    Author: Holub N, Neidhöfer J, Blechert S.
    Journal: Org Lett; 2005 Mar 31; 7(7):1227-9. PubMed ID: 15787473.
    Abstract:
    [reaction: see text] The first enantioselective synthesis of (+)-trans-195A is described. The structure has been constructed by ring-rearrangement metathesis (RRM) and zirconium-mediated Negishi-coupling, used for the first time to prepare 6,6-membered heterocycles, as key steps. By comparison of the synthesized material with the isolated natural product, the absolute configuration of natural trans-195A was determined to be (2R,4aS,5R,8aS)-(-).
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