These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Asymmetric total synthesis of rollicosin.
    Author: Quinn KJ, Isaacs AK, DeChristopher BA, Szklarz SC, Arvary RA.
    Journal: Org Lett; 2005 Mar 31; 7(7):1243-5. PubMed ID: 15787477.
    Abstract:
    [structure: see text] The first total synthesis of rollicosin, a member of a rare subgroup of Annonaceous acetogenins containing two terminal gamma-lactones, is reported. The approach features a highly regio- and stereoselective tandem ring-closing/cross-metathesis reaction for construction of the east-wing lactone and incorporation of the alkyl spacer. Establishment of the C4 stereocenter and addition of the west-wing lactone were achieved by Sharpless asymmetric dihydroxylation and enolate alkylation.
    [Abstract] [Full Text] [Related] [New Search]