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  • Title: [Decurarization using the cation-anion molecular interaction of a myorelaxant and its antagonist].
    Author: Grechishkin LL, Krasnova EI, Indenbom ML.
    Journal: Farmakol Toksikol; 1979; 42(4):362-5. PubMed ID: 157883.
    Abstract:
    In experiments on the cat neuromuscular preparation the authors investigated the anticurare action of the new compound IEM-931 having sulphonate-anionic groups 20 A apart. The new compound administered in a dose of 184 mkM/kg prevents and removes the curare effect of rythetronium which is its structural analogue. Regarding tubocurarine the antagonism is displayed, however, only from the dose of 384 mkM/kg. This indicates that efficacy of the anticurare action of IEM-931 is directly related to complimentarity of the interacting molecule structure. The experiment with regional relaxation of the cat muscles shows that the anticurare action of IEM-931 is realized both in the blood and on the cholinoreceptor. Moreover, as a result of molecular interaction the inactive complex is formed.
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