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  • Title: The roles of receptor and ligand endocytosis in regulating Notch signaling.
    Author: Le Borgne R, Bardin A, Schweisguth F.
    Journal: Development; 2005 Apr; 132(8):1751-62. PubMed ID: 15790962.
    Abstract:
    Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.
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