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  • Title: A MALDI-chip integrated system with a monitoring window.
    Author: Brivio M, Tas NR, Goedbloed MH, Gardeniers HJ, Verboom W, van den Berg A, Reinhoudt DN.
    Journal: Lab Chip; 2005 Apr; 5(4):378-81. PubMed ID: 15791334.
    Abstract:
    The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the "monitoring window" approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
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