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Title: Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment. Author: Gallant JE, Parish MA, Keruly JC, Moore RD. Journal: Clin Infect Dis; 2005 Apr 15; 40(8):1194-8. PubMed ID: 15791522. Abstract: In our large observational cohort, use of tenofovir disoproxil fumarate (n=344) was associated with a greater decline in renal function than was use of alternative nucleoside analogues (n=314). Other associations included a lower CD4 cell count, decreased renal function at baseline, and diabetes. The declines were modest and did not lead to greater rates of discontinuation of therapy.[Abstract] [Full Text] [Related] [New Search]