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  • Title: Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone.
    Author: Mrad K, Sassi S, Smida M, Oubiche F, Mekni A, Romdhane KB.
    Journal: Pathologica; 2004 Dec; 96(6):475-8. PubMed ID: 15792374.
    Abstract:
    BACKGROUND: Primary malignant mesenchymoma of the bone is a rare neoplasm consisting of two or more unrelated malignant mesenchymal components. The literature reports fewer than 20 cases, most of which were composed of osteosarcoma and liposarcoma. OBSERVATION: We report an exceedingly rare case of primary malignant mesenchymoma of bone composed of rhabdomyosarcoma, osteosarcoma, and a minor chondrosarcoma component, arising in the right proximal humerus of a 15-year-old girl. The rhabdomyosarcomatous component was present in the initial biopsy and persisted in surgical specimen following chemotherapy. CONCLUSION: Effect of chemotherapy is enigmatic since rhabdomyosarcomatous component could appear, persist or disappear after chemotherapy according to literature.
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