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  • Title: [Analysis of polymorphic markers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry].
    Author: Tang J, Hou Y.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2005 Apr; 22(2):185-8. PubMed ID: 15793781.
    Abstract:
    With the development of genomics and the accomplishments of human genomic sequencing, polymorphic markers and their analytic approaches are more and more important, and much attention has been paid to the fact that the analysis of single nucleotide polymorphisms utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) is a high-throughput approach. MALDI-TOF MS can also mini-sequence and genotype short tandem repeat. The approaches to analyzing single nucleotide polymorphisms are primer oligonucleotide base extension, ligase reaction, peptide nucleotide acid, invader assay, and so on.
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