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  • Title: Altered mesoaccumbens and nigro-striatal dopamine physiology is associated with stereotypy development in a non-rodent species.
    Author: McBride SD, Hemmings A.
    Journal: Behav Brain Res; 2005 Apr 15; 159(1):113-8. PubMed ID: 15795004.
    Abstract:
    Stress-induced changes in mesoaccumbens dopamine neurophysiology have been associated with the development of stereotypic behaviour in in-bred strains of laboratory rodents. This experiment evaluated whether similar changes are associated with environmentally-induced stereotypic behaviour in a higher-vertebrate species, the horse. D1- and D2-like dopamine receptor densities (B(max)) and dissociation constants (K(d)) were measured in control (n=9) and stereotypy (n=9) horses in the nucleus accumbens, caudate nucleus, putamen, substantia nigra and ventral tegmentum brain regions. Results revealed that stereotypy horses had significantly higher (P<0.05) dopamine D1 and D2 receptor densities (B(max)) in the nucleus accumbens compared to non-stereotypy controls. D1 receptor densities (B(max)) and D2 receptor affinity (K(d)) were also significantly lower in the caudate nucleus brain region of stereotypy horses (P<0.05). No other significant results were observed. These results demonstrate that stereotypy horses have increased activity within the mesoaccumbens dopamine pathway and, thus, that the development of environmentally-induced stereotypy may be associated with changes in motivational systems within the animal.
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