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  • Title: Contrast-enhanced dynamic MR imaging parameters and histological types of invasive ductal carcinoma of breast.
    Author: Takeda Y, Yoshikawa K.
    Journal: Biomed Pharmacother; 2005 Apr; 59(3):115-21. PubMed ID: 15795104.
    Abstract:
    The diagnosis of breast cancer has progressed owing to the improvement of both MRI equipments and MR techniques. CE-MRI is expected to be more useful for diagnosis of the existence and characteristics of breast cancer than mammography and ultrasound. Forty-three breast cancer patients, who underwent breast MRI examination before surgery and had histologically confirmed invasive ductal carcinomas, were included in this study. In 19, seven and 17 of them, carcinomas were histologically classified as papillotubular, solid-tubular, and scirrhous type, respectively. In dynamic MRI studies, the MR parameters were calculated from the signal intensity determined before and at five time-points after a bolus of 0.1 mmol Gd-DTPA/kg in the chosen region of interest (ROI). The differential analysis of MR parameters with reference to histopathology was performed by one-way analysis of variance (ANOVA) in dynamic studies. Four of 15 parameters analyzed, ENH1-2, ENH1, MSLP, and SAT3, were significantly different between papillotubular and scirrhous carcinoma. The dynamic curve of papillotubular carcinoma reached a maximum in the very early phase and then decreased slowly (linear pattern), while that of scirrhous carcinoma peaked in the slightly later phase and then decreased (parabolic pattern). In the differential analysis by Kruskal-Wallis test, although no significant differences were found in any morphological parameters among three histological types, spicula formation and rim enhancement tended to appear comparatively frequently in scirrhous and solid-tubular carcinoma. CE-MRI might reveal the differences of growth characteristics among different histological types of breast carcinomas and provide a diagnostic method useful for estimation of the prognosis of breast cancer.
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