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  • Title: Towards a polymeric binding mimic for cytochrome CYP2D6.
    Author: Rathbone DL, Ali A, Antonaki P, Cheek S.
    Journal: Biosens Bioelectron; 2005 May 15; 20(11):2353-63. PubMed ID: 15797339.
    Abstract:
    A series of fluorescent molecularly imprinted polymers has been prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. Such polymers would have the possibility to form the sensing element in a high-throughput assay for the prediction of CYP2D6 affinity. The imprinted polymers possessed binding-dependent fluorescence. They re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One polymer in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from a drug panel.
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