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  • Title: Novel routes for metabolism of 7-ketocholesterol.
    Author: Jessup W, Brown AJ.
    Journal: Rejuvenation Res; 2005; 8(1):9-12. PubMed ID: 15798369.
    Abstract:
    Oxysterols (oxygenated forms of cholesterol) are present at low levels in the circulation and accumulate is plasma and tissues in some pathologies. In atherosclerotic lesions, 7-oxygenated oxysterols, predominantly 7-ketocholesterol, accumulate and have been implicated in the pathology of the disease. Therefore, knowledge of the mechanisms for 7-ketocholesterol generation and metabolism may provide therapeutic drug targets. There is some in vivo and in vitro evidence that sterol 27-hydroxylase acts on 7-ketocholesterol to initiate its degradation to more polar, water-soluble products. Recent studies indicate an alternative mechanism, in which 7-ketocholesterol is reduced to 7 beta-hydroxycholesterol by 11 beta-hydroxysteroid dehydrogenase type 1.
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