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  • Title: Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept.
    Author: Mor A, Bingham CO, Barisoni L, Lydon E, Belmont HM.
    Journal: J Rheumatol; 2005 Apr; 32(4):740-3. PubMed ID: 15801034.
    Abstract:
    Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine. Agents that neutralize TNF-alpha are effective in the treatment of disorders such as rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), spondyloarthropathies, and inflammatory bowel disease. TNF-alpha antagonist therapy has been associated with the development of antinuclear antibodies (ANA) and double-stranded DNA (dsDNA) antibodies, as well as the infrequent development of systemic lupus erythematosus (SLE)-like disease. We describe the first case of biopsy-confirmed proliferative lupus nephritis and leukocytoclastic vasculitis in a patient treated with etanercept for JRA.
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