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  • Title: Synthesis of the new furo[3,2-h]isoquinoline alkaloid, TMC-120B from Aspergillus ustus.
    Author: Kumemura T, Choshi T, Hirata A, Sera M, Takahashi Y, Nobuhiro J, Hibino S.
    Journal: Chem Pharm Bull (Tokyo); 2005 Apr; 53(4):393-7. PubMed ID: 15802838.
    Abstract:
    A total synthesis of a new furo[3,2-h]isoquinoline alkaloid TMC120-B (2), isolated from Aspergillus ustus together with two related compounds, has been completed in sixteen steps. The key step is the synthesis of the appropriate 3,7,8-trisubstituted isoquinoline framework (23) based on a thermal electrocyclic reaction of the 1-aza 6pi-electron system involving the benzene double bond. In addition, the microwave assisted electrocyclic reaction of this system was newly performed.
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