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  • Title: Isolated vitamin E deficiency with demyelinating neuropathy.
    Author: Puri V, Chaudhry N, Tatke M, Prakash V.
    Journal: Muscle Nerve; 2005 Aug; 32(2):230-5. PubMed ID: 15803482.
    Abstract:
    A 22-year-old man, with a past history of generalized tonic-clonic seizures treated with phenobarbital, presented with spinocerebellar ataxia. The electrophysiological studies revealed a demyelinating motor-sensory neuropathy. The serum vitamin E level was low. Sural nerve biopsy revealed loss of large myelinated fibers with evidence of remyelination. Vitamin E supplementation led to clinical and electrophysiological recovery of sensory conduction and evoked potentials. Motor nerve conduction, however, showed only partial recovery. Vitamin E deficiency leading to a demyelinating neuropathy, as in the present case, suggests that the full spectrum of the disease entity is not fully defined.
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