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  • Title: Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives.
    Author: Akbas E, Berber I.
    Journal: Eur J Med Chem; 2005 Apr; 40(4):401-5. PubMed ID: 15804539.
    Abstract:
    Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two [corrected] 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to<0.0024 mg ml(-1) .
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