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  • Title: Release of anti-PAF activity from PAF-binding human ovarian cancer cells in culture.
    Author: Adamson LM, Hanf V, Mittman SG, Siebert G, Seeger H, Simon WE, Tinneberg HR.
    Journal: Anticancer Res; 1992; 12(2):293-6. PubMed ID: 1580546.
    Abstract:
    The human ovarian cancer cell line EFO-27 in culture spontaneously produced anti-PAF activity, which eluted from HPLC in the range of synthetic PAF. The activity therefore appears to be due to an antagonistic PAF-analogue. It was detected by a suppressed PAF-induced platelet aggregation in vitro. EFO-27 cells were found to be able to bind synthetic PAF with saturable binding kinetics. This binding led to reduced cell proliferation. The production of anti-PAF activity by EFO-27 cells resembles an autocrine growth regulation in the light of recent findings that other malignant transformed cell lines produce PAF-like activity in vitro if stimulated appropriately.
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