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  • Title: Mitochondrial nitric oxide synthase.
    Author: Ghafourifar P, Cadenas E.
    Journal: Trends Pharmacol Sci; 2005 Apr; 26(4):190-5. PubMed ID: 15808343.
    Abstract:
    Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase. The reaction of this NO with superoxide anion yields peroxynitrite, which irreversibly modifies susceptible targets within mitochondria and induces oxidative and/or nitrative stress. In this article, we review the current understanding of the roles of mtNOS as a crucial biochemical regulator of mitochondrial functions and attempt to reconcile apparent discrepancies in the literature on mtNOS.
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