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  • Title: Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts.
    Author: Naidu BN, Sorenson ME, Bronson JJ, Pucci MJ, Clark JM, Ueda Y.
    Journal: Bioorg Med Chem Lett; 2005 Apr 15; 15(8):2069-72. PubMed ID: 15808470.
    Abstract:
    The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity.
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