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  • Title: Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles.
    Author: Sharon A, Pratap R, Tiwari P, Srivastava A, Maulik PR, Ram VJ.
    Journal: Bioorg Med Chem Lett; 2005 Apr 15; 15(8):2115-7. PubMed ID: 15808480.
    Abstract:
    A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.
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