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  • Title: YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. II. Physico-chemical properties and structure elucidation.
    Author: Sohda KY, Hiramoto M, Suzumura K, Takebayashi Y, Suzuki K, Tanaka A.
    Journal: J Antibiot (Tokyo); 2005 Jan; 58(1):32-6. PubMed ID: 15813178.
    Abstract:
    YM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
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