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  • Title: Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus.
    Author: Yang WM, Liu JK, Qin XD, Wu WL, Chen ZH.
    Journal: Z Naturforsch C J Biosci; 2004; 59(7-8):481-4. PubMed ID: 15813365.
    Abstract:
    In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated. The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
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