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  • Title: Preparing for efficacy trials of vaginal microbicides in Indian women.
    Author: Joshi S, Solomon S, Mayer K, Mehendale S.
    Journal: Indian J Med Res; 2005 Apr; 121(4):502-9. PubMed ID: 15817959.
    Abstract:
    Vaginal microbicides are topical compounds that are expected to protect women against vaginal transmission of HIV and other sexually transmitted pathogens. A large number of compounds are being evaluated as possible microbicides. Considering the spread of the HIV epidemic among women in India, clinical trials on microbicides starting from the Phase I safety and acceptability studies to Phase III efficacy trials are important. Conducting efficacy trials is a major endeavour and this review discusses challenges and issues and the preparatory steps to make such efficacy trials possible in India.
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