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  • Title: Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia.
    Author: Choi JW, Son BK.
    Journal: Clin Chim Acta; 2005 May; 355(1-2):83-9. PubMed ID: 15820481.
    Abstract:
    BACKGROUND: This study investigated the associations of soluble transferrin receptor (sTfR), log ferritin, the ratio of sTfR to log ferritin (sTfR-F index), and the log of the ratio of sTfR to ferritin [log(sTfR/F)] vs. reticulocyte production during iron deficiency. METHODS: Fluorescent intensity of reticulocytes, immature reticulocyte fraction (IRF), reticulocyte maturity index (RMI), sTfR, and serum ferritin were measured in 149 adolescents. RESULTS: There were no significant differences in reticulocyte parameters between the iron deficiency anemia (IDA) subjects with sTfR> or =4.9 mg/l and those with sTfR<4.9 mg/l. However, IDA subjects with log ferritin <0.73 microg/l exhibited significantly higher mean values for IRF and RMI, compared to those with log ferritin > or =0.73 microg/l (2.75+/-1.36% vs. 1.45+/-1.01%, p<0.05; 2.76+/-1.31% vs. 1.46+/-1.09%, p<0.05). In the non-IDA group, reticulocytes averaged 0.97+/-0.31% in subjects with sTfR> or =2.1 mg/l, which were significantly above the values in those with sTfR<2.1 mg/l (0.72+/-0.16%, p=0.005), but no significant differences were observed in reticulocyte parameters between the subjects with log ferritin > or =1.35 microg/l and those with log ferritin <1.35 microg/l. Correlation coefficients of log ferritin vs. RMI (r=-0.41) were higher than those of sTfR, sTfR-F index, and log(sTfR/F) vs. RMI (r=0.24, r=0.30, and r=0.28, respectively) in IDA subjects. CONCLUSION: Reticulocytopoiesis is more closely associated with log ferritin value than with sTfR concentrations in IDA patients, although sTfR significantly reflects erythropoietic activity in non-IDA subjects.
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