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  • Title: Axon guidance: opposing EPHects in the growth cone.
    Author: Klein R.
    Journal: Cell; 2005 Apr 08; 121(1):4-6. PubMed ID: 15820672.
    Abstract:
    Cells communicate with other cells via (trans) interaction between membrane-linked ephrins and Eph receptors. In this issue of Cell, Pfaff and colleagues (Marquardt et al., 2005) demonstrate that coexpressed ephrin-As and Ephs do not interact in cis but rather segregate into separate membrane domains, from which they signal opposing effects during motor axon guidance.
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