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  • Title: Clonal cytogenetic abnormalities in patients with chronic myeloid leukemia in complete cytogenetic response to imatinib mesylate.
    Author: Espinet B, Oliveira AC, Boqué C, Domingo A, Alonso E, Solé F.
    Journal: Haematologica; 2005 Apr; 90(4):556-8. PubMed ID: 15820956.
    Abstract:
    The emergence of clonal chromosomal abnormalities in Philadelphia-negative cells during treatment with imatinib in patients with Philadelphia-positive chronic myeloid leukemia has been reported. We add information to this issue presenting a series of 29 patients in complete cytogenetic response after imatinib treatment, three of whom developed clonal aberrations.
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