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  • Title: [Pathomorphology of adenohypophysis in cases of massive obstetric hemorrhages (morphometric and immunohistochemical studies)].
    Author: Milovanov AP, Matsionis AE, Makarenko IuM.
    Journal: Arkh Patol; 2005; 67(1):14-7. PubMed ID: 15822786.
    Abstract:
    There have been performed morphometric and immunohistochemical examinations of adenohypophysis of 15 females who died of massive post-partum hemorrhages. The revealed changes in the form of hypertrophy of the basophilic cells are the initial stages of Sheehan's syndrome developing as a result of long-term progression of hypopituitarism. Massive obstetric bleeding causes severe complications-posthemorrhagic shock, the pathogenetic mechanism of which includes necrosis of the cells in the anterior part of the hypophysis. Cause-effect relations were shown for the amount of the post-partum blood loss and the revealed pathomorphologic changes in the hypophysis. Hyperproduction of ACTH by the basophilic cells of the adenohypophysis revealed by immunohistochemical analysis is a compensatory mechanism under the conditions of acute adrenal insufficiency inherent in any shock including posthemorrhagic.
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