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  • Title: Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice.
    Author: Noh HS, Kim DW, Kang SS, Cho GJ, Choi WS.
    Journal: Brain Res; 2005 Apr 25; 1042(1):114-8. PubMed ID: 15823260.
    Abstract:
    We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.
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