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  • Title: Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas.
    Author: Wei JT, Mott LA, Baron JA, Sandler RS, Polyp Prevention Study Group.
    Journal: Cancer Epidemiol Biomarkers Prev; 2005 Apr; 14(4):1026-7. PubMed ID: 15824186.
    Abstract:
    We did a secondary analysis of data from three large colorectal adenoma chemoprevention trials to assess the association between 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor use and reduced risk of recurrent colorectal adenomas. Reported use of HMG-CoA reductase inhibitors was not associated with a reduced recurrence of colorectal adenomas, multiple adenomas, or advanced adenomas. Lack of statistical power from limited exposure to HMG-CoA reductase inhibitors might be responsible for the lack of association.
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