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  • Title: An experimental model of ameboma in guinea pig.
    Author: Bhatti HS, Bhushnurmath S, Mahajan RC, Ganguly NK, Sehgal R.
    Journal: Exp Parasitol; 1992 May; 74(3):283-9. PubMed ID: 1582480.
    Abstract:
    Among the wide variety of clinicopathological manifestations of intestinal amebiasis, amebomas occur rarely and their pathogenesis is not well understood. When cholesterol-fed, 2- to 4-week-old guinea pigs were infected intracecally with a virulent, monoaxenic strain of Entamoeba histolytica, gross and histologically characteristic amebomas developed in 85% of the animals by the 3rd day, in 94% by the 9th day, and in 96% by the 12th day postinfection, by which time most of them had died. Amebomas were confirmed by histopathology. Thus, a model of consistent production of amebomas was documented.
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