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  • Title: Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmus.
    Author: Glasauer S, Strupp M, Kalla R, Büttner U, Brandt T.
    Journal: Ann N Y Acad Sci; 2005 Apr; 1039():528-31. PubMed ID: 15827015.
    Abstract:
    The potassium channel blocker 4-aminopyridine (4-AP) restored vertical smooth pursuit and gaze holding in light in one patient with upbeat (UBN) and in one with downbeat nystagmus (DBN). Without a visible target, however, 4-AP had no effect on UBN, but DBN vanished. We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN.
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