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  • Title: Familial occurrence of pruritic urticarial papules and plaques of pregnancy.
    Author: Weiss R, Hull P.
    Journal: J Am Acad Dermatol; 1992 May; 26(5 Pt 1):715-7. PubMed ID: 1583169.
    Abstract:
    BACKGROUND: The occurrence of pruritic urticarial papules and plaques of pregnancy (PUPPP) was noted in four women with unusual family relationships. OBJECTIVE: The purpose of the study was to document the occurrence of PUPPP in these families and to make observations on their possible relevance. METHODS: Case reports of the four patients are detailed. Histologic and HLA studies are recorded. RESULTS: In both families, sisters were married to brothers. A common paternal influence is suggested. CONCLUSION: We postulate that PUPPP may be a maternal response to a circulating paternal factor for which tolerance develops in subsequent pregnancies.
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