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Title: Combined chemoradiotherapy in small cell lung cancer. Author: Hahn NM, Hanna N. Journal: Hematol Oncol Clin North Am; 2005 Apr; 19(2):321-42, vii. PubMed ID: 15833409. Abstract: Combined chemoradiotherapy is the established standard of care for limited stage small cell lung cancer; it provides cure in 15% to 25% of patients. Early concurrent therapy imparts a 5% long-term survival benefit compared with sequential therapy. Hyperfractionated delivery of radiotherapy may provide a small incremental benefit when compared with standard fractionation. Radiotherapy dose escalation and reduced radiotherapy volumes are feasible; however, survival benefit has not been confirmed. Cisplatin and etoposide remain the preferred chemotherapy agents. New chemotherapeutic agents and novel treatment approaches are under intense investigation.[Abstract] [Full Text] [Related] [New Search]