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  • Title: Clonostachysins A and B, new anti-dinoflagellate cyclic peptides from a marine-derived fungus.
    Author: Adachi K, Kanoh K, Wisespongp P, Nishijima M, Shizuri Y.
    Journal: J Antibiot (Tokyo); 2005 Feb; 58(2):145-50. PubMed ID: 15835726.
    Abstract:
    The two new anti-dinoflagellates, clonostachysins A and B, were obtained from a marine sponge derived fungus Clonostachys rogersoniana strain HJK9. Their chemical structures were determined by spectroscopic studies as highly N-methylated cyclic peptides of the nine amino acids. The absolute stereochemistry was elucidated by the advanced Marfey's method. Both clonostachysins A and B exhibited a selectively inhibitory effect on a dinoflagellate Prorocentrum micans at 30 microM, but had no effect on other microalgae and bacteria even at 100 microM.
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