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  • Title: [Distribution of Orexin-A mRNA expression in different organs and its variation in acute inflammation].
    Author: Yan GT, Lin J, Liao J.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2005 Apr; 17(4):207-10. PubMed ID: 15836821.
    Abstract:
    OBJECTIVE: To explore the distribution of Orexin-A mRNA expression in different organs, and its variation in acute inflammation, and to evaluate the role of Orexin-A in acute inflammatory responses. METHODS: Hypothalamus, adipose tissue, lung, stomach, duodenum, liver, spleen and testis of male Sprague-Dawley rats (including normal and those of intestinal ischemia/reperfusion injury model) were harvested, and reverse transcription-polymerase chain reaction(RT-PCR) was used to assess Orexin-A mRNA expression in different tissues of normal rats, and that in the hypothalamus of ischemia/reperfusion injured rats. RESULTS: All tissues expressed Orexin-A mRNA, and it was especially high in the stomach, lung and kidney. After the acute stimulus of ischemia/reperfusion injury, Orexin-A mRNA expression showed a trend of fluctuant declination in the hypothalamus. CONCLUSION: Orexin-A mRNA is widely expressed in the major organs, and it has a time-dependent response to acute inflammatory stimuli. The results suggest that its expression variation may be used as a novel marker for acute inflammation.
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