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  • Title: Design, synthesis and biological evaluation of novel, simplified analogues of laulimalide: modification of the side chain.
    Author: Paterson I, Menche D, Håkansson AE, Longstaff A, Wong D, Barasoain I, Buey RM, Díaz JF.
    Journal: Bioorg Med Chem Lett; 2005 May 02; 15(9):2243-7. PubMed ID: 15837302.
    Abstract:
    Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
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