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  • Title: Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.
    Author: Barraja P, Sciabica L, Diana P, Lauria A, Montalbano A, Almerico AM, Dattolo G, Cirrincione G, Disarò S, Basso G, Viola G, Dall'Acqua F.
    Journal: Bioorg Med Chem Lett; 2005 May 02; 15(9):2291-4. PubMed ID: 15837311.
    Abstract:
    A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.
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