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  • Title: Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives.
    Author: Yao NH, Liu G, He WY, Niu C, Carlson JR, Lam KS.
    Journal: Bioorg Med Chem Lett; 2005 May 02; 15(9):2325-9. PubMed ID: 15837318.
    Abstract:
    Twenty-five N-demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC-MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis.
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