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  • Title: New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors.
    Author: Feixas J, Giovannoni MP, Vergelli C, Gavaldà A, Cesari N, Graziano A, Dal Piaz V.
    Journal: Bioorg Med Chem Lett; 2005 May 02; 15(9):2381-4. PubMed ID: 15837329.
    Abstract:
    A series of potent PDE5 inhibitors with high selectivity versus PDE6 isoenzymes was identified.
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