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  • Title: Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model.
    Author: Grell SN, Riber U, Tjørnehøj K, Larsen LE, Heegaard PM.
    Journal: Vaccine; 2005 May 16; 23(26):3412-23. PubMed ID: 15837365.
    Abstract:
    Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFalpha levels and less virus-specific IFNgamma release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong "inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.
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