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  • Title: Breakthrough candida Infection in a preterm infant with congenital cutaneous Candida albicans infection.
    Author: Adler A, Litmanovitz I, Regev R, Arnon S, Bauer S, Dolfin T.
    Journal: Am J Perinatol; 2005 Apr; 22(3):169-72. PubMed ID: 15838753.
    Abstract:
    Amphotericin B is the primary antifungal agent used for candida sepsis in neonates. Breakthrough candidemia was not reported in neonates during either amphotericin B or liposomal amphotericin B (AmBisome) treatment. We describe a case of a premature infant with congenital cutaneous candida infection, who had two episodes of breakthrough infection, from Candida albicans and Candida parapsilosis, while he was treated with amphotericin B and AmBisome, respectively. We discuss the pathogenesis of breakthrough infections, and the relevance of antifungal resistance and sensitivities testing.
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