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  • Title: [Significance of extracellular matrix determined by immunostains and histochemical stains in a case of pulmonary epithelioid hemangioendothelioma].
    Author: Saito H, Ishida M, Kakutani A, Kushima R, Yamamoto K, Chano T, Okabe H.
    Journal: Rinsho Byori; 2005 Mar; 53(3):213-6. PubMed ID: 15839050.
    Abstract:
    We have analyzed extracellular matrix(ECM) of a case of pulmonary epithelioid hemangioendothelioma (PEH). Type IV collagen and laminin were existed in the ECM and were condensed around the tumor cell nests in meshwork pattern. Elastica-van Gieson stain revealed elastic fibers in this meshwork. These findings suggested that enhanced basement membrane protein synthesis in PEH seems to be responsible for the accumulation of abundant ECM. Analysis of the ECM seems to be quite useful for the differential diagnosis of this tumor.
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