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  • Title: A unique monoclonal antibody that recognizes mature p17 of HIV-1 but not its precursor.
    Author: Saitoh A, Tanaka N, Nakata A, Ikuta K, Shinagawa H.
    Journal: Microbiol Immunol; 1992; 36(1):105-11. PubMed ID: 1584067.
    Abstract:
    The entire and partial gag regions of human immunodeficiency virus type 1 (HIV-1) were overproduced in Escherichia coli and used for epitope mapping of antibodies against p17. We found that a mouse monoclonal antibody to p17, V17 recognizes the mature p17 but not the unprocessed Gag proteins containing the entire p17 moiety. Further analysis revealed that V17 recognizes the C-terminal 12-amino-acid region of p17 having free C-terminus. This monoclonal antibody may be useful for monitoring the maturation of virus particles.
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