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  • Title: Mechanism of spaceflight-induced changes in left ventricular mass.
    Author: Summers RL, Martin DS, Meck JV, Coleman TG.
    Journal: Am J Cardiol; 2005 May 01; 95(9):1128-30. PubMed ID: 15842991.
    Abstract:
    Decrements in left ventricular (LV) mass observed after microgravity exposure have been previously postulated to be a central component of spaceflight-induced cardiovascular deconditioning. In this study, echocardiographic measurements of LV mass in astronauts demonstrated a comparative 9.1% reduction in postflight LV mass that returned to preflight values by the third day of recovery. A ground-based study in normal subjects determined that these pre- to postflight LV mass changes could be reproduced by simple dehydration. Reductions in LV mass observed immediately after spaceflight may be secondary to simple physiologic fluid exchanges.
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