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  • Title: Oxygen-enhanced proton imaging of the human lung using T2.
    Author: Pracht ED, Arnold JF, Wang T, Jakob PM.
    Journal: Magn Reson Med; 2005 May; 53(5):1193-6. PubMed ID: 15844155.
    Abstract:
    Magnetic susceptibility gradients caused by tissue/air interfaces lead to very short T(2)* times in the human lung. These susceptibility gradients are dependent on the magnetic susceptibility of the respiratory gas and therefore should influence T(2)* relaxation. In this work, a technique for quantitative T(2)* mapping of the human lung during one breath hold is presented. Using this method, the lung T(2)* relaxation time was measured under normoxic (room air, 21% O(2)) and hyperoxic (100% O(2)) conditions to verify this assumption. The mean T(2)* difference between room air and 100% O(2) is about 10% and contains ventilation information, since only ventilated regions contribute to signal change due to different susceptibility gradients.
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