These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Catalepsy induced by striatal acetylcholinesterase inhibition with fasciculin in rats.
    Author: Castelló ME, Bolioli B, Dajas F.
    Journal: Pharmacol Biochem Behav; 1992 Mar; 41(3):547-50. PubMed ID: 1584833.
    Abstract:
    The acetylcholinesterase inhibitor peptide fasciculin (FAS) was bilaterally injected into the striatum of rats. Twenty-four hours after injection, animals showed a cataleptic syndrome that was potentiated by haloperidol (HAL). The catalepsy was significantly decreased by IP atropine. Biochemically, only an increase of the homovanillic acid in the striatum was found 24 h and 7 days after FAS treatment. Seven days after the intrastriatal FAS injection, there was no HAL potentiation of catalepsy, which was even lower than that of rats treated with IP HAL after intrastriatal injection of saline. Results are interpreted as showing the central role of the cholinergic system in the induction of catalepsy in the rat.
    [Abstract] [Full Text] [Related] [New Search]