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  • Title: Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids.
    Author: Coro J, Pérez R, Rodríguez H, Suárez M, Vega C, Rolón M, Montero D, Nogal JJ, Gómez-Barrio A.
    Journal: Bioorg Med Chem; 2005 May 16; 13(10):3413-21. PubMed ID: 15848753.
    Abstract:
    Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.
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